Brain metastases are the most feared and debilitating complication of systemic cancers. They affect approximately 170 000 patients a year, with the most common primary tumors being lung cancer, breast cancer, and melanoma.1 The traditional approach for patients with brain metastases has been whole-brain radiation therapy (WBRT), irrespective of lesion number or primary site.
Raizer J. Radiosurgery and Whole-Brain Radiation Therapy for Brain Metastases: Either or Both as the Optimal Treatment. JAMA. 2006;295(21):2535–2536. doi:10.1001/jama.295.21.2535
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