[Skip to Content]
[Skip to Content Landing]
June 7, 2006

High-Dose Statins and the IDEAL Study

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;295(21):2476-2479. doi:10.1001/jama.295.21.2477-a

To the Editor: The IDEAL study1 is 1 of 4 recent large clinical trials that have examined whether high-dose statins improve outcomes compared with conventional doses. The first 2 trials (PROVE-IT2 and A to Z3) enrolled patients with acute coronary syndromes (ACS), whereas the latter 2 trials (TNT4 and IDEAL1) enrolled patients with stable coronary artery disease. The results from these trials appear to conflict: PROVE-IT and TNT found statistically significant differences, whereas A-to-Z and IDEAL did not. Some of these conflicts may be related to the study designs.