[Skip to Navigation]
Sign In
Grand Rounds
Clinician's Corner
June 28, 2006

Depression and Cardiovascular Disease: Healing the Broken-Hearted

Author Affiliations

Grand Rounds at the University of California, San Francisco Medical Center: David S. Cooper, MD, Contributing Editor, JAMA .


Author Affiliation: Veterans Affairs Medical Center and University of California, San Francisco Medical Center.

JAMA. 2006;295(24):2874-2881. doi:10.1001/jama.295.24.2874

Major depressive disorder is a risk factor for the development of incident coronary heart disease events in healthy patients and for adverse cardiovascular outcomes in patients with established heart disease. Depression is present in 1 of 5 outpatients with coronary heart disease and in 1 of 3 outpatients with congestive heart failure, yet the majority of cases are not recognized or appropriately treated. It is not known whether treating depression improves cardiovascular outcomes, but antidepressant treatment with selective serotonin reuptake inhibitors is generally safe, alleviates depression, and improves quality of life. This article evaluates the importance of major depression in patients with cardiovascular disease, and provides practical guidance for identifying and treating this disorder.

Add or change institution