To the Editor: In their study of coffee, CYP1A2 genotype, and myocardial infarction risk, Ms Cornelis and colleagues1 concluded that carriers of the CYP1A2*1F allele, which they define as a slow allele for caffeine metabolism, have an increased risk of nonfatal myocardial infarction compared with carriers of the CYP1A2*1A allele. The increased risk associated with coffee intake was only observed among the carriers of the *1F allele, and the effect was similar in smokers and nonsmokers.
Ingelman-Sundberg M, Sim SC, Nebert DW. Coffee, Myocardial Infarction, and CYP Nomenclature. JAMA. 2006;296(7):764–766. doi:10.1001/jama.296.7.764-b
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