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September 20, 2006

High-Sensitivity C-Reactive Protein and Fracture Risk in Elderly Women

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(11):1349-1355. doi:10.1001/jama.296.11.1353

To the Editor: Reduced bone mass and increased risk of fracture have been associated with inflammatory diseases such as rheumatoid arthritis,1 inflammatory bowel disease,2 and ankylosing spondylitis.3 Inflammatory cytokines stimulate osteoclastic bone resorption4 and inhibit osteoblast function.5 We hypothesized that serum high-sensitivity C-reactive protein (hsCRP), a marker of systemic inflammation, is associated with fracture risk.

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