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September 27, 2006

Neurotoxicity of Mercury in Dental Amalgam

JAMA. 2006;296(12):1461-1463. doi:10.1001/jama.296.12.1462-a

To the Editor: In his Editorial on neurotoxic risk of mercury in dental amalgam, Dr Needleman1 comments on the results of 2 randomized controlled trials in the same issue of JAMA.2,3 The findings in the trials of no effect of exposure to mercury-containing amalgam on neurobehavioral and neuropsychological outcomes after 5 to 7 years are reassuring. Although we agree with Needleman's general comments on the limitations of these studies, there are 2 issues that may assist health care professionals in counseling patients and guide future research considerations.