In Reply: My Editorial argued that, given limitations in design in the studies by Bellinger et al1 and DeRouen et al,2 it was unscientific to assume a no-effect conclusion. The limitations were statistical power too low to find a relatively small harmful effect, follow-up too brief, and nondifferential errors in exposure measurement that would lead to a null bias. Neither Dr Ismail nor Dr Fung and colleagues addressed these criticisms.
Needleman HL. Neurotoxicity of Mercury in Dental Amalgam—Reply. JAMA. 2006;296(12):1461–1463. doi:10.1001/jama.296.12.1462-b
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