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October 4, 2006

Shift Shown in Influenza A Adamantane Resistance

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(13):1585-1587. doi:10.1001/jama.296.13.1585-b

To the Editor: Dr Bright and colleagues1 reported an increase in adamantane-resistant influenza A viruses in the United States: less than 2% before 2002, 14.5% from October 2004 through March 2005, and 92.3% from October 1 to December 31, 2005. The authors commented that exposure to amantadine and rimantadine did not seem to explain the increased resistance, because only a minority of the samples was from nursing home settings in which the medications are most likely used. However, the viral resistance may be associated with the recent wide-scale use of another adamantane compound, memantine.