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October 11, 2006

Translation of Research Evidence From Animals to Humans

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(14):1727-1732. doi:10.1001/jama.296.14.1731

To the Editor: Most medical therapies in use today were initially developed and tested in animals,1 yet animal experiments often fail to replicate when tested in rigorous human trials.2,3 We conducted a systematic review to determine how often highly cited animal studies translate into successful human research.

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