To the Editor: Most medical therapies in use today were initially developed and tested in animals,1 yet animal experiments often fail to replicate when tested in rigorous human trials.2,3 We conducted a systematic review to determine how often highly cited animal studies translate into successful human research.
Hackam DG, Redelmeier DA. Translation of Research Evidence From Animals to Humans. JAMA. 2006;296(14):1727–1732. doi:10.1001/jama.296.14.1731
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