To the Editor: The OASIS-6 trial1 was not the first to demonstrate that a 7-day (or hospitalization duration) treatment with an anticoagulant is superior to a 48-hour infusion of UFH therapy. Both the Assessment of the Safety and Efficacy of New Thrombolytic Regimen 3 (ASSENT-3) trial2 and Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Events (ESSENCE) trial3 have shown similar findings. A trial of anticoagulant with an equal duration of UFH did not display this difference.4 The differences in treatment duration in OASIS-6 may have affected the development of deep vein thrombosis (DVT) and pulmonary embolism.
Peeters MJ, Sydoruk B. Fondaparinux in Patients With ST-Segment Elevation Myocardial Infarction. JAMA. 2006;296(17):2087–2089. doi:10.1001/jama.296.17.2088-a
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