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JAMA Revisited
December 17, 2014

Is Aspirin a Dangerous Drug?

JAMA. 2014;312(23):2577. doi:10.1001/jama.2013.279902

Aspirin, or acetylsalicylic acid, has been used in enormous quantities throughout most of the world for some forty-five years. Many persons seem to have a mild idiosyncrasy to this drug or to the other salicylates and consequently avoid its use; the vast majority take it with apparent impunity. Although toxic effects have been discussed in these columns,1 severe reactions are certainly rare in relation to the enormous quantities consumed. Deaths from aspirin have been reported; these appear to have been more frequent in England than in this country.

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