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November 15, 2006

Prostate Cancer in a Transgender Woman 41 Years After Initiation of Feminization

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(19):2312-2317. doi:10.1001/jama.296.19.2316

To the Editor: The development of prostate cancer after orchiectomy is rare. In transgender women, the longest duration between initiation of estrogen therapy and diagnosis previously reported was 12 years.1,2 We report a case of a male-to-female transgender woman with locally advanced prostate cancer diagnosed 41 years after feminization.