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December 6, 2006

Efficacy of Varenicline for Smoking Cessation

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(21):2555-2556. doi:10.1001/jama.296.21.2555-a

To the Editor: In their clinical trials of varenicline for smoking cessation, Dr Gonzales and colleagues,1 Dr Jorenby and colleagues,2 and Dr Tonstad and colleagues3 used broad exclusion criteria, particularly for psychiatric disorders of major depressive disorder within the past year; history of or a current panic disorder, psychosis, bipolar disorder, or eating disorder; or alcohol or drug abuse or dependency within the past year. In addition, Tonstad et al3 excluded potential participants who were taking antidepressants, antipsychotics, or mood stabilizers or anticonvulsants.