To the Editor: The study of aminotransferase levels by Dr Watkins and colleagues1 found a high incidence of alanine aminotransferase (ALT) elevations in healthy participants who were randomized to receive medications containing acetaminophen (paracetamol); this was not found in participants randomized to placebo. We have a number of concerns with the methods used in this study.
Yuan Y, Thabane M, Thabane L, Hunt RH. Acetaminophen and Aminotransferase Elevations. JAMA. 2006;296(23):2798–2799. doi:10.1001/jama.296.23.2798-a
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