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December 20, 2006

Acetaminophen and Aminotransferase Elevations

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(23):2798-2799. doi:10.1001/jama.296.23.2798-a

To the Editor: The study of aminotransferase levels by Dr Watkins and colleagues1 found a high incidence of alanine aminotransferase (ALT) elevations in healthy participants who were randomized to receive medications containing acetaminophen (paracetamol); this was not found in participants randomized to placebo. We have a number of concerns with the methods used in this study.