In Reply: In response to Dr Bhala and colleagues, the definition of major bleeding that we used is standard for studies of VTE, and we believe that blood loss equivalent to 2 units is clinically important.1 Bleeding that was considered abnormal (ie, more than trivial) but that did not satisfy criteria for major bleeding was classified as “minor.” Intracranial and fatal bleeds were described in the article; the remaining major bleeding episodes were intra-articular (n = 2), genitourinary (n = 1), gastrointestinal (n = 1), and retroperitoneal (n = 1) in the unfractionated heparin group and gastrointestinal (n = 6), intra-articular (n = 2), and from a surgical site (n = 1) in the low-molecular-weight heparin group.
Kearon C, Ginsberg JS, Julian JA, Gent M, Fixed-Dose Heparin (FIDO) Investigators FT. Fixed-Dose Unfractionated Heparin vs Low-Molecular-Weight Heparin for Venous Thromboembolism—Reply. JAMA. 2007;297(3):261–263. doi:10.1001/jama.297.3.263-a
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