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January 24/31, 2007

Psoriasis and Risk of Myocardial Infarction

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(4):361-363. doi:10.1001/jama.297.4.361-b

To the Editor: Dr Gelfand and colleagues1 studied the risk of MI in patients with psoriasis. The authors found that psoriasis is an independent risk factor for MI, especially for young patients with severe disease, and hypothesized that exaggerated immune activity could lead to a higher risk for MI by linking TH1 diseases to atherosclerosis and coronary artery disease. However, the exact mechanism by which TH1-mediated diseases predispose patients to vascular disease remains unclear.