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February 14, 2007

Targeted Treatment of Active Trachoma

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(6):588-590. doi:10.1001/jama.297.6.588-b

To the Editor: In their study of targeted trachoma treatment, Dr Atik and associates1 describe the effect of selective antibiotic treatment of trachoma in Vietnamese communes with low rates of active trachoma. They conclude that targeted treatment of school children with disease (and their families) may interfere with the development of protective immunity and lead to increasing infection rates. We feel these conclusions are not justified because of the inherent difficulties in studying trachoma treatment of communities with a low prevalence (<5%) of active disease in young children.