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February 14, 2007

Targeted Treatment of Active Trachoma—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(6):588-590. doi:10.1001/jama.297.6.589

In Reply: Our prospective study examined the effect of azithromycin treatment on active trachoma and C trachomatis infection rates in an endemic area, with 2-year follow-up beyond the last treatment to determine risks of reemergence for both. We are aware of no similar studies despite documentation of reemergence 6 to 24 months following treatment.1 Dr Mabey and colleagues note 3 studies showing sustained infection reduction after mass treatment. However, 1 study found increasing infection prevalence from 2 to 12 months without further follow-up,2 another found infection reemergence in different villages from 2 to 24 months,3 and only 1 showed sustained reduction at 24 months.4