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The World in Medicine
February 21, 2007

Genetic Stroke Risk

JAMA. 2007;297(7):686. doi:10.1001/jama.297.7.686-a

Individuals with a particular gene variant have a substantially increased risk of cerebral infarction, the most common type of stroke, according to findings by Japanese researchers (Kubo M et al. Nat Genet. doi:10.1038/ng1945 [published online January 7, 2007]).

In a case-control study of 1112 Japanese individuals with cerebral infarction and 1112 controls, the researchers identified one gene variant, PRKCH, that was associated with a 40% increased risk of lacunar stroke. (About 20% of all strokes and 40% of cerebral infarctions are this subtype.) The researchers confirmed the association in another population of Japanese patients with cerebral infarction.

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