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February 28, 2007

Presenting Plasma HIV RNA Level and Rate of CD4 T-Cell Decline

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(8):805-807. doi:10.1001/jama.297.8.805-b

To the Editor: In their study, Dr Rodriguez and colleagues1 challenge the long-held view that baseline plasma HIV-1 RNA level is the best predictor of the rate of CD4 cell decline among untreated HIV-infected individuals, initially put forward by Mellors et al in 1997.2 There are several methodological issues that may have contributed to this controversy.