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Book and Media Reviews
March 21, 2007

Developmental Origins of Health and Disease

Author Affiliations

Book and Media Reviews Section Editor: John L. Zeller, MD, PhD, Fishbein Fellow, JAMA.

JAMA. 2007;297(11):1259-1263. doi:10.1001/jama.297.11.1259-b

Developmental cues occurring at the earliest stages of human development can have lifelong influence on common chronic health conditions of children and adults. Two paradigms that address these issues are now converging. The first, called the life course approach to chronic disease, posits that ultimate health outcomes result from diverse factors, ranging from environmental and societal factors through the biological, that interact dynamically from conception through adulthood. This approach, which tends to emphasize population-based research, societal factors, and public health implications, is represented admirably by A Life Course Approach to Chronic Disease Epidemiology: Tracing the Origins of Ill-Health From Early to Adult Life.1