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Lab Reports
April 4, 2007

Down Syndrome Drugs

JAMA. 2007;297(13):1423. doi:10.1001/jama.297.13.1423-d

Blocking an inhibitory neurotransmitter can improve performance of several memory tasks in a mouse model of Down syndrome, according to new research from Stanford University, in Palo Alto, Calif (Fernandez F et al. Nat Neurosci. doi:10.1038/nn1860 [published online February 25, 2007]).

The Down syndrome mouse shows some of the features of the human disorder, including deficits in memory for facts and events as well as excessive neuronal inhibition in the dentate gyrus region of the brain, an effect mediated by the neurotransmitter GABA.