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April 4, 2007

Proton Pump Inhibitor Therapy and Hip Fracture Risk

JAMA. 2007;297(13):1429-1430. doi:10.1001/jama.297.13.1429-a

To the Editor: While secondary causes of osteoporosis frequently contribute to hip fractures,1,2 studies of these associations may be hampered by a lack of control for relevant confounding variables. In assessing the association of gastric acid suppression with hip fractures, Dr Yang and colleagues3 did not address vitamin D status as a potential confounder.