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April 4, 2007

High-Altitude Pulmonary Edema and Patent Foramen Ovale

JAMA. 2007;297(13):1432-1433. doi:10.1001/jama.297.13.1432-b

To the Editor: Dr Allemann and colleagues1 reported a significant association between a PFO and HAPE. As they note, the cause-and-effect relationship between these 2 abnormalities is not clear. The patient description cited as evidence of PFO being a cause for susceptibility to HAPE does not present a strong argument in support of this hypothesis. This patient was treated with calcium channel blockers in addition to the closure of his PFO, and calcium channel blockers have been shown to be highly effective for preventing HAPE.2