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April 11, 2007

Folic Acid Supplementation and Cardiovascular Diseases

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(14):1549-1550. doi:10.1001/jama.297.14.1549-a

To the Editor: In their meta-analysis of randomized controlled trials of folic acid supplementation and risk of cardiovascular disease, Dr Bazzano and colleagues1 provided a clear description of their inclusion criteria and study selection process. Using multiple databases when searching for studies that meet meta-analysis inclusion criteria may help avoid selection bias.2 Failure to search multiple health databases can result in missing up to half of the relevant literature.3