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April 11, 2007

Folic Acid Supplementation and Cardiovascular Diseases

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(14):1549-1550. doi:10.1001/jama.297.14.1549-b

To the Editor: Several large prospective observational studies and a recent meta-analysis1 suggested an association between elevated levels of homocysteine and risk of cardiovascular diseases. A population-based cohort study found that folate supplementation is effective in decreasing total homocysteine concentration.2 However, the meta-analysis of randomized controlled trials by Dr Bazzano and colleagues3 did not find any effect of folic acid supplementation on the risk of cardiovascular diseases or all-cause mortality among patients with a prior history of vascular disease.