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April 11, 2007

Folic Acid Supplementation and Cardiovascular Diseases—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(14):1549-1550. doi:10.1001/jama.297.14.1550

In Reply: In response to Dr Mahid and colleagues, although we did not have access to EMBASE, we did conduct bibliographic searches of review articles and included abstracts from the “grey literature” through these searches. For example, the results of Baker et al were published only in abstract form.1 We agree that searching this type of literature is particularly important for finding negative studies, because positive findings are more likely to be published in peer-reviewed journals indexed by MEDLINE. In the case of our pooled analysis, we identified no association between folic acid supplementation and the risk of cardiovascular diseases or all-cause mortality.