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May 16, 2007

Iron Reduction and Cardiovascular Outcomes

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(19):2075-2076. doi:10.1001/jama.297.19.2075-a

To the Editor: The iron-heart hypothesis postulated a primary protective effect of iron depletion against ischemic heart disease.1 The report of the Iron (Fe) and Atherosclerosis Study (FeAST) by Dr Zacharski and colleagues2 had 2 key limitations as a general test of the idea: it was a trial of secondary prevention, and the iron-reduction protocol fell short of achieving full iron depletion.