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June 6, 2007

Genomics and Public Health Research—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(21):2347-2348. doi:10.1001/jama.297.21.2347-b

In Reply: We agree with Dr Khoury and colleagues. Human genomics is an excellent example of the need to improve the research roadmap and strengthen practice-based research and phase 3 (T3) translation. The best discoveries in human genomics mean little if they cannot be effectively and efficiently delivered to the patients who could benefit. Projects that might connect practice-based researchers with genomics researchers include identifying cancer links between phenotype and genotype and identifying genetic markers for predicting medication response. Identifying the best antihypertensive medication based on genetic disposition may help customize and improve hypertension management.