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June 13, 2007

Long-term Mortality Associated With Aprotinin Following Coronary Artery Bypass Graft Surgery

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(22):2475-2477. doi:10.1001/jama.297.22.2476-a

To the Editor: In their study of risk of aprotinin, Dr Mangano and colleagues1 found that aprotinin was associated with increased long-term risk of mortality following CABG surgery when compared with nonaprotinin antifibrinolytics. There are some covariates that are important to consider in this type of study, and it is not clear from this article whether they were included in the analysis.