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June 13, 2007

Genetic Association Studies and False Discoveries

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(22):2477-2478. doi:10.1001/jama.297.22.2477-b

To the Editor: Genetic association studies of common traits are frequently limited by failures of replication and insufficient correction for multiple testing.1,2 Dr Smith and colleagues3 evaluated the association of 24 candidate genes with the risk of venous thrombosis. I have a number of concerns about the use in this study of the false discovery rate (FDR) q value, an emerging statistic that may assist in evaluation of the validity of genetic association findings.4,5