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June 13, 2007

Genetic Association Studies and False Discoveries—Reply

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(22):2477-2478. doi:10.1001/jama.297.22.2478-a

In Reply: The FDR q value is an approach to the problem of multiple comparisons that, although novel in epidemiology, has already become standard for reporting high-throughput genomic studies.1 Dr Horne maintains that the best statistical practice in genetic association studies is correction of P values for multiple comparisons, citing Havill and Dyer.2 However, that article describes 3 approaches to multiple testing, one of which is FDR; none of the 3 is declared “best statistical practice,” and the authors state that “which method to use is unclear.”