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June 20, 2007

Polycystic Ovary Syndrome and Infertility

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;297(23):2582-2583. doi:10.1001/jama.297.23.2582-b

To the Editor: The Clinical Crossroads by Dr Legro1 discussed options for the treatment of women with polycystic ovary syndrome (PCOS), including issues related to fertility. However, the article did not consider oral administration of low-dose dexamethasone to suppress biosynthesis of adrenal androgens. As monotherapy for the amelioration of hyperandrogenic symptoms, dexamethasone has been found to be effective in inducing ovulation in combination with clomiphene citrate.2,3