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July 4, 2007

Timing of Glycoprotein IIb/IIIa Inhibitors in Acute Coronary Syndromes

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(1):37-38. doi:10.1001/jama.298.1.37-a

To the Editor: In the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) Timing trial, Dr Stone and colleagues1 reported that more than 10% of patients developed thrombocytopenia, defined as a platelet count of less than 150 000/μL. Prior studies have defined thrombocytopenia as either less than 100 000/μL or at least a 25% decrease from baseline, with incidence ranging from 0.5% to 5.6%.2,3 It is unclear how many patients in the ACUITY trial developed significant thrombocytopenia using these alternative definitions.