To the Editor: In 1968, Grande1 critically reviewed purported weight and body composition effects of 3 weight reduction diets by invoking the laws of thermodynamics. Grande showed inconsistencies that rendered the publications inconclusive. Four decades later, serious data inconsistencies are still appearing in studies of diet intervention, such as the A TO Z Weight Loss Study by Dr Gardner and colleagues.2
Heymsfield SB, Blackburn GL. Comparison of Weight-Loss Diets. JAMA. 2007;298(2):173–175. doi:10.1001/jama.298.2.173-b
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