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Lab Reports
August 1, 2007

Neurodegenerative Mouse

JAMA. 2007;298(5):505. doi:10.1001/jama.298.5.505-d

A team led by researchers at the University of Michigan in Ann Arbor has generated a new mouse model of neurodegeneration that carries a mutation also seen in some patients with the inherited nerve condition called Charcot-Marie-Tooth disorder (Chow CY et al. Nature. doi:10.1038/nature05876 [published online ahead of print June 17, 2007]).

The “pale tremor” mouse carries a mutation in a gene called Figure 4 encoding an enzyme that acts on certain phospholipids in the cell. The mice had abnormal pigmentation, early neurodegeneration, and large vacuoles in affected cells.