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August 8, 2007

Aspirin Dose and Cardiovascular Disease Prevention

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(6):625-626. doi:10.1001/jama.298.6.625-b

To the Editor: In their systematic review of aspirin dose for the prevention of cardiovascular disease, Dr Campbell and colleagues1 conclude that currently available data do not support the routine long-term use of aspirin dosages greater than 75 mg/d to 81 mg/d in the setting of cardiovascular disease prevention. The definition of cardiovascular disease includes stroke, transient ischemic attack, and myocardial infarction. We agree with the authors that aspirin dosage in excess of 300 mg/d is not justified, but suggest the potential for better stroke prevention using aspirin dosage of 160 mg/d compared with 75 mg/d to 81 mg/d.