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Health Agencies Update
December 24/31, 2014

Unique Mice May Help Reveal Human Response to Chemical Exposure

JAMA. 2014;312(24):2608. doi:10.1001/jama.2014.17033

New research conducted in part by scientists at the National Institutes of Health suggests that a genetically diverse mouse model, referred to as “Diversity Outbred” mice, will help predict the range of biological responses that may occur within a population after different chemical exposures (French JE et al. Environ Health Perspect.doi:10.1289/ehp.1408202 [published online November 6, 2014]). Traditionally, isogenic mice are used to assess the effects of exposure; however, because of lack of genetic diversity, these models may not accurately predict the range of sensitivities to chemicals in humans.