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October 10, 2007

Genetic Associations With Age-Related Macular Degeneration

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(14):1637. doi:10.1001/jama.298.14.1637-a

To the Editor: In their study of the Age-Related Eye Disease Study (AREDS) participants,1 Dr Seddon and colleagues investigated whether genetic variants were associated with progression of age-related macular degeneration. In the article, they did not present the main results stratified by treatment assignment. Results for the antioxidants-plus-zinc group and the placebo group would have been a useful addition to Table 6 in the article. The authors did note that genotype and treatment had no significant interaction, but interaction tests may have very low statistical power.