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January 27, 2015

Protocolized Sedation in Critically Ill Children

Author Affiliations
  • 1Department of Medicine and Interdepartmental Division of Critical Care, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2015;313(4):363-364. doi:10.1001/jama.2015.1

Light sedation1 or no sedation2 has become the therapeutic goal in critically ill adults. Large randomized trials3-5 and systematic reviews6,7 have demonstrated that this goal is feasible, safe, and beneficial. The benefits include shorter durations of mechanical ventilation and stay in the intensive care unit (ICU).2-4 However, prospective data supporting the benefits of minimizing sedation in children are lacking, with only 1 randomized trial of 102 children showing shorter durations of mechanical ventilation and ICU stay with daily interruption of midazolam infusions compared with no interruption.8

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