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October 17, 2007

Validity of Reported Genetic Risk Factors for Acute Coronary Syndrome

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(15):1757-1759. doi:10.1001/jama.298.15.1757-a

To the Editor: The study of genetic risk factors for acute coronary syndrome (ACS) by Dr Morgan and colleagues1 calls into serious question numerous reported associations between specific genes and ACS. Rather than finding this a reason to lose hope of identifying genetic contributions to ACS or other common diseases, we consider it a guide to improving such efforts, serving as a powerful reminder both of the limitations inherent to “candidate gene” approaches and the need for rigorous replication of research findings before clinical application. This article indicates the maturation of the study of the genetics of common complex disease.