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October 17, 2007

Validity of Reported Genetic Risk Factors for Acute Coronary Syndrome

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(15):1757-1759. doi:10.1001/jama.298.15.1758-a

To the Editor: The study by Dr Morgan and colleagues1 maintained that aside from the β-fibrinogen gene FGB (P = .03), none of the other 85 gene variants previously associated with ACS could be replicated in their study. However, we note that the most significant association with a variant of thrombospondin 2 (THBS2) (P = .002) was overlooked despite replicating an association2,3 with respect to allele and magnitude.