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October 17, 2007

Validity of Reported Genetic Risk Factors for Acute Coronary Syndrome

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(15):1757-1759. doi:10.1001/jama.298.15.1758-b

To the Editor: Dr Morgan and colleagues1 were unable to replicate previously reported positive association findings of 84 genetic variants with ACS in a large-scale case-control study. The authors discussed a number of factors contributing to the nonreplication of results in candidate gene association studies and suggest that whole genome analyses may be a useful alternative. The ability to evaluate the entire genome for genetic association with common multifactorial diseases (such as ACS) is certainly an exciting development. However, these studies do not resolve most of the problems already present in candidate gene analyses and may lead to even more false results.