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November 28, 2007

Risk of Diabetes in Patients With Rheumatoid Arthritis Taking Hydroxychloroquine

JAMA. 2007;298(20):2368-2370. doi:10.1001/jama.298.20.2368-b

To the Editor: In their multicenter study of the association between treatment with hydroxychloroquine and the risk of diabetes mellitus, Dr Wasko and colleagues1 followed up a large cohort of patients with rheumatoid arthritis for 21.5 years. After adjustment for diabetes risk factors and prednisone use, the authors concluded that treatment with hydroxychloroquine was associated with a reduced risk of developing diabetes. The use of prednisone was evaluated as “ever” or “never” and the percentage of time using the drug during the observation period was calculated.