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December 19, 2007

Claims of Sex-Gene Interactions

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2007;298(23):2741-2742. doi:10.1001/jama.298.23.2741-b

To the Editor: In their assessment of genetic associations, Dr Patsopoulus and colleagues1 analyzed claims of sex-gene interactions.1 They seem to imply that the criterion standard for evaluating such interactions is the statistical significance level of the test for sex by gene interaction, generally stated in terms of an odds ratio or relative risk (RR). However, in those instances in which the underlying incidence rates differ by sex, such tests of interaction are generally arbitrary.