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Comment & Response
February 3, 2015

Proposed Shift in Screening for Breast Cancer—Reply

Author Affiliations
  • 1Department of Medicine, University of Washington, Seattle
  • 2Faculty of Medicine, Hebrew University Medical School, Jerusalem, Israel
  • 3Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem, Israel
JAMA. 2015;313(5):525-526. doi:10.1001/jama.2014.17442

In Reply Drs Levine and Steinberg are concerned about the number of women to be screened and the risks and costs of population-based screening for mutations in BRCA1 and BRCA2. It is accepted that a healthy woman with severe family history of breast or ovarian cancer should be offered testing for actionable mutations in BRCA1 and BRCA2 because cancer risk to mutation carriers can be significantly reduced by surgical intervention.1,2