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Comment & Response
February 10, 2015

Contact Precautions for Patients With Multidrug-Resistant Pathogens—Reply

Author Affiliations
  • 1VA Maryland Healthcare System, Baltimore
  • 2Wayne State University, Detroit, Michigan
  • 3Division of Infectious Diseases, University of Iowa College of Medicine, Iowa City
JAMA. 2015;313(6):630. doi:10.1001/jama.2014.17448

In Reply We are aware of the large MOSAR-ICU quasi-experimental trial but disagree that it evaluated the addition of contact precautions to standard precautions. To our reading, the MOSAR study had 2 main phases: (1) comparing enhanced hand hygiene and chlorhexidine bathing with a baseline period and (2) comparing rapid vs conventional screening and isolation of patients with multidrug-resistant organisms, including MRSA and VRE.1 Dr Derde and colleagues imply that their trial compared standard precautions plus chlorhexidine bathing without contact precautions vs active surveillance for MRSA or VRE with contact precautions for those positive for MRSA or VRE.