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July 5, 2006

Treatment of Antiphospholipid Antibody Syndrome

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(1):42-43. doi:10.1001/jama.296.1.42

To the Editor: In their Clinical Review of antiphospholipid antibody syndrome (APS) management, Dr Lim and colleagues1 examine evidence for treatment of 2 distinct groups of patients: those with antiphospholipid antibodies and those with definite APS. Classification criteria for definite APS, including laboratory criteria, have been recently updated.2 The new criteria reinforce the importance of persistent positivity and require positive laboratory test results at least 12 weeks apart. Data from the literature derived from patients with a single positive antiphospholipid antibody test do not apply to patients with definite APS.