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July 19, 2006

Low-Fat Diet and Cardiovascular Disease

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(3):279-281. doi:10.1001/jama.296.3.279-b

To the Editor: In the report of the Women's Health Initiative (WHI) Dietary Modification Trial by Dr Howard and colleagues,1 reduced consumption of total fat and increased consumption of fruits, vegetables, and grains did not significantly affect the incidence of coronary heart disease or stroke among postmenopausal women during 8.1 years of follow-up. The authors' primary explanation for the negative results was that the magnitude of dietary changes may have been insufficient to significantly alter risk.