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July 26, 2006

Use of Aspirin as Primary Prevention of Cardiovascular Events

Author Affiliations

Letters Section Editor: Robert M. Golub, MD, Senior Editor.

JAMA. 2006;296(4):391-392. doi:10.1001/jama.296.4.391-b

To the Editor: The meta-analysis of randomized controlled trials of aspirin for the primary prevention of cardiovascular events by Dr Berger and colleagues1 reported that aspirin decreased the incidence of myocardial infarction in men, but not in women. However, the aspirin dose in the 5 trials that included men ranged from 75 mg/d to 500 mg/d. The dose in the 3 trials that included women ranged from 50 mg/d (100 mg every other day) to 100 mg/d.